A trial comparing Stanford V chemotherapy with ABVD chemotherapy for advanced Hodgkin lymphoma

Cancer type:

Blood cancers
Hodgkin lymphoma
Lymphoma

Status:

Results

Phase:

Phase 2/3

This trial compared standard ABVD combination chemotherapy with a newer combination of chemotherapy and radiotherapy called Stanford V for people with advanced Hodgkin lymphoma. This trial was supported by Cancer Research UK.

Doctors usually treat advanced Hodgkin lymphoma with ABVD chemotherapy and sometimes radiotherapy. ABVD includes the drugs doxorubicin, bleomycin, vinblastine and dacarbazine.

When this trial was done, earlier trial results suggested that a newer combination of chemotherapy and radiotherapy called Stanford V might be a useful treatment for advanced Hodgkin lymphoma. Standard V includes the drugs mustine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide and steroids.

The aim of this trial was to compare the standard treatment with the newer treatment to find out

  • Which works best for advanced Hodgkin lymphoma
  • More about the side effects

Summary of results

The trial team found that Stanford V combination chemotherapy with radiotherapy was no better than ABVD with radiotherapy for people with advanced Hodgkin lymphoma.

520 people took part in this trial

  • Half had ABVD chemotherapy
  • Half had Stanford V chemotherapy

After chemotherapy, some patients went on to have radiotherapy.

The trial team analysed the results in 2009. They looked at how well the treatment worked and how many people lived for five years after treatment. They found no difference between the 2 different groups.

The most common side effect in both groups was a drop in blood cell counts. People in the ABVD group had more lung problems.

The trial team concluded that there was no evidence that adding more chemotherapy drugs to the standard ABVD combination with radiotherapy helped to treat advanced Hodgkin lymphoma.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Peter Hoskin

Supported by

Cancer Research UK
Chugai Pharma UK Ltd
National Institute for Health Research Cancer Research Network (NCRN)

Other information

This is Cancer Research UK trial number CRUK/02/002.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle - 99

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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