A trial comparing immediate treatment with active surveillance for newly diagnosed prostate cancer (ProSTART)

Cancer type:

Prostate cancer




Phase 3

This trial was trying to find out if it is best for men with prostate cancer contained within the prostate gland to have treatment straight away or to have active surveillance. This trial was supported by Cancer Research UK

If you are diagnosed with prostate cancer, your doctor may suggest that you have treatment such as surgery to remove the prostate gland, radiotherapy or brachytherapy. If the cancer is completely contained inside the prostate gland, the aim of these treatments is to cure the cancer. You may hear them called radical treatments.

But all treatments have side effects. For some men, the side effects of treatment are worse than any problems the cancer might cause. Prostate cancer can grow so slowly that it never causes any symptoms. So, some men have active surveillance. This means you don’t have treatment straight away. Your doctor keeps a close eye on you to check for any signs that the cancer is growing. If it does, then you and your doctor will decide which treatment is best for you.

This trial was for men who had prostate cancer that their doctors thought was unlikely to grow or spread for some years. The aim of the trial was to compare active surveillance with treatment intended to cure the cancer, to see which was better for this group of men.

Summary of results

We have contacted the trial team who tell us they don’t expect to be making results available for this trial. The researchers were unable to recruit enough patients.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr C Parker

Supported by

Cancer Research UK
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer

Other information

This is Cancer Research UK trial number CRUK/07/037.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 4033

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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