"I am glad that taking part in a trial might help others on their own cancer journey.”
A trial comparing docetaxel and ramucirumab to docetaxel alone for non small cell lung cancer that has come back after treatment
This trial compared a drug called ramucirumab (pronounced ram-oo-seer-oo-mab) and docetaxel chemotherapy to docetaxel alone to treat non small cell lung cancer. It was for people whose cancer had spread to another part the body and had come back after treatment.
Ramucirumab is a type of biological therapy called a monoclonal antibody. Monoclonal antibodies can seek out cancer cells by looking for particular proteins on the cell surface. Blocking them may stop the cancer growing.
Doctors want to find out if ramucirumab and docetaxel is better than docetaxel alone to treat non small cell lung cancer that had spread and had come back after treatment.
The aims of this trial were to find out
- If ramucirumab and docetaxel are better at treating non small cell lung cancer that had spread than docetaxel alone
- About the side effects
Summary of results
The trial team found that ramucirumab with docetaxel helped people to live longer when they had non small cell lung cancer that had spread.
- 628 people had ramucirumab and docetaxel
- 625 people had docetaxel and a dummy drug (
When the researchers looked at the average time people were free of their cancer they found that it was
- 4½ months for those who had ramucirumab and docetaxel
- 3 months for those who had docetaxel and the dummy drug
The average overall time people lived was
- 10½ months for those who had ramucirumab and docetaxel
- 9 months for those who had docetaxel and the dummy drug
The most common side effects in both groups were
- A drop in blood cells causing an increased risk of infection, bruising and bleeding
- Tiredness (fatigue)
- Loss of appetite
- Feeling or being sick
- Hair loss
- Sore mouth
- Shortness of breath
The trial team concluded that people with non small cell lung cancer that had spread lived longer when treated with ramucirumab and docetaxel than with docetaxel alone.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Conrad Lewanski
Eli Lilly and Company Limited