A trial of anastrozole for hormone receptor positive gynaecological cancers (PARAGON)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Cervical cancer
Ovarian cancer
Womb (uterine or endometrial) cancer




Phase 2

This trial is looking at anastrozole for gynaecological cancers that have spread. It is for post menopausal women Open a glossary item who have a gynaecological cancer that responds to changes in hormone levels (is hormone receptor positive). This trial is supported by Cancer Research UK.

More about this trial

Some cancer cells need hormones to grow. If the amount of hormone reaching the cancer cell is blocked then the cancer may stop growing. Hormone therapy can block hormones reaching hormone receptors Open a glossary item on cancer cells. Your doctor will test to see if your cancer has hormone receptors.

In this trial doctors are looking at a hormone therapy drug called anastrozole.  The aims of trial are to

  • Find out if anastrozole helps women with hormone receptor positive gynaecological cancer
  • Learn more about the side effects

Who can enter

You may be able to enter this trial if

You cannot enter this trial if you

  • Have already had an aromatase inhibitor, tamoxifen or progesterone to treat your gynaecological cancer
  • Are taking hormone replacement therapy (HRT) Open a glossary item or only stopped taking it in the last 4 weeks
  • Have had any other cancer in the last 5 years unless your doctors think there is no risk of it coming back
  • Have certain problems with your liver or kidneys

Trial design

This trial will recruit 350 women from around the world.

Everybody taking part takes an anastrozole tablet once a day. As long as you don't have any bad side effects, you can take anastrozole for as long as it helps you.

The trial team will ask you to fill out a questionnaire

  • Before you start treatment
  • Once a month for 3 months
  • Then every 3 months until you stop treatment

The questionnaire will ask about side effects and how you have been feeling. This is called a quality of life study.

Hospital visits

You will see the doctors and have some tests before you start treatment. The tests include

  • Physical examination
  • Blood tests
  • CT scan
  • Bone density scan (DXA scan Open a glossary item)

You see the trial team for blood tests once a month for 3 months. Then you see the trial team for blood tests and a CT scan every 3 months. You have a bone density scan every 1 or 2 years. You continue with these tests until your cancer starts to grow again.

Side effects

The most common side effects of anastrozole are

  • Hot flushes
  • Dryness of the vagina
  • Painful joints
  • Tiredness (fatigue)
  • Feeling or being sick
  • Mood changes
  • Loss of bone density which can increase the risk of bones breaking
  • Headaches
  • Hair thinning
  • Skin rash

There is more information about the side effects of anastrozole in our cancer drugs section.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Richard Edmondson

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NHS Greater Glasgow and Clyde
NIHR Clinical Research Network: Cancer
University of Glasgow

Other information

This is Cancer Research UK trial number CRUK/10/056

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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