Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study using PET-CT scan to detect thyroid cancer and salivary gland cancer
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at a PET-CT scan to detect thyroid cancer and salivary gland cancer.
More about this trial
Doctors can use a PET-CT scan to diagnose thyroid cancer and salivary gland cancer. Researchers think that a PET-CT scan may be better at detecting these cancers than the SPECT scan doctors currently use.
To get a clearer picture a
In this study everyone will have a PET-CT scan done using the BF4 radioactive tracer.
The aims of this study are to find
- How much of the radioactive tracer is taken up by thyroid cancer an salivary gland cancer
- How safe the radioactive tracer is
Who can enter
The following bullet points list the entry conditions for this study. If you are unsure about any of these speak with your doctor or the study team. They will be able to advise you.
You may be able to join this study if are going to St Guy’s and St Thomas’ Hospital and all of the following apply. You
- Have thyroid cancer or salivary gland cancer
- Are able to have surgery to remove the cancer
- Are 18 to 80 years old
You cannot join this study if any of these apply. You
- Have already had treatment for thyroid cancer or salivary gland cancer
- Have had medication containing iodine, for example amiodarone, in the past year
- Have had a
contrast mediumas an injection in the past 6 months
- Have had thyroid hormones in the past 2 months
- Have any other problem that the study team think will affect you taking part
- Are pregnant or breastfeeding
This is a phase 1 study. The researchers need 20 people to join. There are 2 groups in this study, group A and group B.
You will have the PET-CT scans done on the same day. You cannot eat or drink, except water, for 6 hours before the scans.
You have a small plastic tube (
- Your first scan takes about 1½ hours
- People in group B then have another scan that takes 30 minutes
- People in group A have another scan 2 hours after you had the injection
- Everyone has a final scan taken 4 hours after the injection
During the day you will give 3 urine samples.
When you have your surgery the researchers will do some extra tests on a sample of cancer tissue that is removed. They are looking for a substance called NIS in the tissue. The results of this test will be compared with the results of the PET-CT scan.
Taking part in the study will not interfere with your care. But there will be an extra visit to the hospital.
You see a member of the research team at Guy’s Hospital to have some tests before you take part in the study.
You go to the Clinical PET Centre at St Thomas’ Hospital for the scans.
During the scans you will a heart trace (
A member of the team will phone the day after to make sure you are all right.
PET-CT scans are a safe test. The radioactive substance in the injection is a very small amount and the radiation goes away quickly. After the scan it is best not to have close contact with pregnant women, babies or children for at least 6 hours.
We have information about PET-CT scan.
How to join a clinical trial
Professor Valerie Lewington
Guy's and St Thomas' NHS Foundation Trust
King's College London
Kings Health Partners
NIHR Clinical Research Network: Cancer