A study to understand more about an eye cancer called uveal melanoma (PROGENOM)

Cancer type:

Eye cancer
Head and neck cancers





This study is gathering information from blood and tissue samples, which may help to predict outlook (prognosis Open a glossary item) and identify new treatments for people with uveal melanoma.

Uveal melanoma is a type of eye cancer. The uvea is the middle tissue layer of the eyeball.

Scientists want to identify which genes Open a glossary item and proteins behave abnormally in this disease. By studying blood and tissue samples from people having surgery to remove uveal melanoma, they hope to

  • Find features of uveal melanoma that would help them tell whether the cancer was likely to spread
  • Develop a blood test which would show if a cancer had spread when this had been missed by other tests
  • Find possible targets in the cancer tissue that may respond to current treatment, or give clues to help design new treatments

Who can enter

You can enter this study if

  • Your doctor thinks you may have a type of eye cancer affecting the tissues of the middle layer of your eye (uveal melanoma)
  • You are due to have surgery to the affected eye
  • You are between 18 and 90 years of age

Trial design

The study has already recruited more than 800 people and aims to recruit about 2,000. People taking part may give blood samples for the study. They also give the study team permission to use some of the eye tissue removed during surgery for research.

These samples are being used in research studies and projects conducted by the University of Liverpool, Liverpool Ocular Oncology Research Group (LOORG) and people they work with (collaborators) in this country and abroad.

You can read more about the various research projects on the LOORG website.

Hospital visits

You will give your study blood samples at your routine hospital appointments. So you do not have to make any extra visits to hospital to take part in this study.

Side effects

As there are no additional treatments in this study outside of the normal care that you receive, there are no side effects.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Sarah Coupland

Supported by

Aintree University Hospitals NHS Foundation Trust
Clatterbridge Cancer Centre NHS Foundation Trust
Fight for Sight (British Eye Research Foundation)
North West Cancer Research
Pathological Society
Royal Liverpool and Broadgreen Hospital Charitable Funds
Royal Liverpool and Broadgreen University Hospital NHS Trust
University of Liverpool

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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