A study to find out why certain people develop oesophageal cancer (ChOPIN)

Cancer type:

Oesophageal cancer

Status:

Open

Phase:

Other

This study is looking at whether your genes affect your risk of developing cancer of the food pipe (oesophageal cancer). You can take part if you have Barrett’s oesophagus or oesophageal cancer. You can also take part if you have inflammation of the oesophagus (oesophagitis) caused by long term acid indigestion (reflux) or hiatus hernia.

 

More about this trial

There are several risk factors for oesophageal cancer. These include things such as lifestyle, the environment or genetic makeup Open a glossary item.

This study will collect blood samples from people who have reflux (also called erosive) oesophagitis, Barrett’s oesophagus or oesophageal cancer to study their DNA Open a glossary item. Researchers have already identified some genes that may affect the risk of oesophageal cancer, but they want to learn more.

In this study, the researchers will collect blood samples from people to help find out possible causes of oesophageal cancer that are related to their genes.

The aims of the study are to find out why

  • Some people develop Barrett’s oesophagus
  • Some people with Barrett’s oesophagus then develop oesophageal cancer

You won’t get any direct benefit from taking part in this trial, nor will it affect any treatment you have. But it will help researchers find out more about the genetic causes of oesophageal cancer.

Who can enter

You can enter this trial if you

  • Have been diagnosed with reflux oesophagitis, Barrett’s oesophagus, hiatus hernia or oesophageal cancer
  • Are willing to give a blood sample
  • Are at least 18 years old

Trial design

You will have a 2 blood samples taken about 3 years apart during a routine hospital visit.

Hospital visits

You will have your blood tests at the hospital, during an outpatient appointment. You will not have to make an extra trip.

Your treatment and hospital appointments will carry on as normal.

Side effects

As there are no treatments involved in this trial, the only side effect you may have is a small bruise when the blood sample is taken.

Location

Aberystwyth
Ashington
Ashton-under-Lyne
Aylesbury
Barnsley
Barnstaple
Bath
Bishop Auckland
Blackpool
Bolton
Bradford on Avon
Bridgend
Bristol
Burnley
Burton on Trent
Carlisle
Chester
Chorley
Coventry
Dartford
Dorset
Dunfermline
Edinburgh
Exeter
Falkirk
Gillingham
Gloucester
Harrogate
Hull
Isleworth
Kettering
Kirkcaldy
Leeds
Leicester
Liverpool
London
Luton
Macclesfield
Maidstone
Manchester
Margate
Middlesbrough
Milton Keynes
Northamptonshire
Norwich
Nottingham
Nuneaton
Oakham
Plymouth
Port Talbot
Portsmouth
Redditch
Salford
Shrewsbury
South Shields
Southampton
Stafford
Stevenage
Stirling
Stockton-on-Tees
Stoke-on-Trent
Sunderland
Sutton
Swansea
Swindon
Torquay
Truro
Wakefield
Walsall
Warrington
Weston Super Mare
Wigan
Wolverhampton
York

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Janusz Jankowski

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Plymouth Hospitals NHS trust
Plymouth University Peninsula Schools for Medicine and Dentistry
Wellcome Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

5956

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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