A study to find out more about the causes of some types of lymphoma and chronic leukaemia

Cancer type:

Blood cancers
Chronic leukaemia
Chronic lymphocytic leukaemia (CLL)
Hairy cell leukaemia
Low grade lymphoma
Non-Hodgkin lymphoma





This study is looking at blood, bone marrow, tissue and spit (saliva) samples from people with white blood cell (lymphocyte) disorders, to discover more about the causes and possible future treatments.

Conditions where lymphocytes have become cancerous are called lymphoproliferative disorders and include

Doctors want to find out more about these cancerous cells. In this study you will give samples of blood and any extra bone marrow Open a glossary item or tissue you may have removed during routine procedures. You will also give a sample of spit (saliva). Researchers will look at both abnormal and normal cells in these samples. They will look for genes, including a particular gene called the ‘immunoglobulin gene’ that help the cancer cell to survive. And, for other gene and chromosome changes that may in future help them predict the outcome of these diseases.

The aim of this study is to understand more about how changes to certain genes, proteins and sugars could affect how these diseases develop.  This may help develop new treatments for these conditions in future.

You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the results of the study will be used to help people with cancer in the future.

Who can enter

You can enter this study if you have any of the following cancers

Trial design

Everyone taking part will have a study blood test at the time they are diagnosed, and when you come to the hospital for your follow up appointments, so the team can monitor changes in the blood cells. You will also give a sample of spit (saliva).

The team will ask permission to study any stored samples of bone marrow or lymphatic tissue that you have had removed as part of your routine treatment.  They will also look at your medical notes to see how you are getting on.

Hospital visits

You will have your study blood test and give your saliva sample when you are already at the hospital for your follow up appointments. So you will not need to make any extra visits to hospital.

Side effects

As there are no treatments in this study, there are no side effects. You may have a small bruise where you had your blood tests.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr N K Potter

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Kay Kendall Leukaemia Fund
Tenovus Solentside Committee
University Hospital Southampton NHS Foundation Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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