A study to find genes that may increase thyroid cancer risk

Cancer type:

Thyroid cancer





In this study people who had thyroid cancer or thyroid growths had blood taken and completed questionnaires to find genes that may increase risk of thyroid cancer.

More about this trial

We know from research that genetic factors may affect the risk of thyroid cancer.

In this study, the researchers looked at the genes Open a glossary item of a large number of people who had thyroid growths (adenomas Open a glossary item) or who had been diagnosed with thyroid cancer.

They looked for common gene faults that may have increased thyroid cancer risk. They also found out more about the patients’ family history to see if any of their relatives also had thyroid cancer.

The aim of the study was to identify genes that might have increased the risk of thyroid cancer.

Summary of results

One of the genes the team looked at is called HABP2 G534E.

The researchers asked 2,105 people with thyroid cancer to

  • complete a questionnaire
  • give a blood sample

They used the blood samples to find out how many of them had the HABP2 G534E gene.

The team also looked at 5,172 people from the general population to see how many of them had the HABP2 G534E gene.

When they looked at the results for the 2 groups the team found similar numbers of people had the HABP2 G534E gene in both groups.

So the researchers concluded that the HABP2 G534E gene wasn’t likely to increase the risk of thyroid cancer.  

The study team are continuing to identify other genes that may increase the risk. When these results are published we will update this summary.

We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team who did the research. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Ian Tomlinson

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Oxford

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 5449

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

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