"I am glad that taking part in a trial might help others on their own cancer journey.”
A study of growth hormone levels and responses to chemotherapy
This study is looking at levels of growth hormones in the blood before and after chemotherapy. It is for people who have bowel cancer, non small cell lung cancer or cancer at the junction of your food pipe and stomach ( gastro oesophageal cancer).
Doctors are now looking for people with bowel cancer to take part.
More about this trial
Doctors often use chemotherapy to treat cancer. It may help to control cancer symptoms and can help people to live longer. But over a period of time, the drugs may stop working. This is described as the cancer becoming
One thing that may affect how well chemotherapy works is the level of growth hormones in the blood. Growth hormones are proteins that send signals to cells telling them to grow.
In this study, the researchers want to find out:
- if they can measure changes in the levels of growth hormones in the blood of people having chemotherapy
- whether different growth hormone levels affect how well chemotherapy works
Who can enter
You can enter this trial if you:
- have bowel cancer that is stage 4, non small cell lung cancer that is stage 3b or stage 4, or gastro oesophageal cancer that is stage 2, 3 or 4
- have cancer that can be measured on a CT scan
- are going to have chemotherapy
- finished any earlier chemotherapy at least 24 weeks (nearly 6 months) ago
- are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- have satisfactory blood test results
- are at least 18 years old
You cannot enter this trial if you:
- have had radiotherapy, surgery (apart from a
biopsy), or an experimental drug in the last month
- can’t have
- are taking part in another clinical trial looking at an experimental treatment
- have any other condition which the study doctors think could affect you taking part
Everybody taking part in this study has chemotherapy. The treatment you have will depend on the type of cancer you have, but you will have
Doctors are currently looking for people with bowel cancer. They hope that around 40 people will take part. Everyone has 3 blood tests on the first day of their chemotherapy. They have the tests:
- before starting chemotherapy
- about 2 hours after starting the treatment
- and about 4 hours after starting treatment
They will also have blood tests 2 weeks later if they are at the hospital for a routine visit on that day. The researchers hope this will help them work out the best time to measure an increase in growth hormone levels.
If there is a sample of cancer tissue available from when you had surgery or a
Taking part in this study will not involve any extra hospital visits. Your doctor will be able to explain how often you need to go to hospital to have chemotherapy and any other tests or scans.
You may have a small bruise where you give extra blood samples.
How to join a clinical trial
Dr S. Van Schaeybroeck
Belfast Health & Social Care Trust
Experimental Cancer Medicine Centre (ECMC)