A study looking at a new type of MRI scan with CT scans to plan treatment and see how well radiotherapy works for people with lung cancer

Cancer type:

Lung cancer
Non small cell lung cancer

Status:

Open

This study is looking at whether a new type of MRI scan used along with CT scans improves the way radiotherapy is planned for people with lung cancer.

More about this trial

When planning radiotherapy for people with lung cancer, doctors try to avoid as much healthy lung tissue as possible. But this can be difficult because scans do not show healthy lung tissue very clearly. If a large dose of radiotherapy is given there is a risk of inflammation of the lungs which can lead to a dry cough or shortness of breath. This is called radiation pneumonitis.

There is a new type of MRI scan which involves breathing in a special gas. The researchers are calling it a gas MRI scan. The scan is like a regular MRI scan but by inhaling the gas the doctors should be able to see which parts of the lungs are working well. These are the areas that need to be avoided when planning radiotherapy.

Radiotherapy is usually planned with CT scans. Researchers want to see if doing a gas MRI scan as well can improve radiotherapy planning for people with a type of lung cancer called non small cell lung cancer.  They also want to

  • Find out if the gas MRI scan can reduce the risk of radiation pneumonitis
  • See if the gas MRI scan can show doctors how well the lungs are working before and after treatment
  • Test whether new types of MRI scans are better at showing lung cancer than a standard MRI

Who can enter

You may be able to join this study if all of the following apply. You

You cannot join this study if any of these apply. You

  • Have a condition which would stop you from being able to have radiotherapy
  • Are pregnant or there is any possibility you could become pregnant
  • Can’t understand English without the need of an interpreter

Trial design

The researchers need about 20 people to join this study.  Everybody taking part will have extra scans during radiotherapy planning. Taking part in the study does not affect the treatment you have.

You will have 2 extra CT scans at the same time as the CT scan you would have routinely for radiotherapy planning. After this, you will have 2 types of MRI scan. For one you breathe in a special gas. For the other you have an injection using a contrast medium Open a glossary item. Both of these will make the scans clearer.

Hospital visits

The additional CT scans and MRI scans will be done on the day you have your radiotherapy planning. The CT scans will be in the morning and the MRI scans in the afternoon. This means that you will have a longer day at the hospital than if you were just having standard radiotherapy planning. The scans will be done at 2 different hospitals but these are next door to each other.

You will have another CT and MRI scan 3 months after you finish your radiotherapy.

Side effects

Having a CT scan involves being exposed to some radiation. The radiation is kept to the minimum necessary, and won't make you feel unwell. The risk of the radiation causing any problems in the future is very small.

There are side effects from the different types of MRI scan but these are mild and don’t last for long.

The side effects from the gas MRI scans include

  • Increased heart rate
  • Slight decrease in the oxygen levels in your blood, making you feel light headed
  • A feeling of tightness in your chest
  • Tickly throat

The side effects from the MRI using a contrast medium include

  • Headache
  • Feeling sick
  • Low blood pressure
  • Light headedness

Location

Sheffield

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Matthew Hatton

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Sheffield Hospitals Charity
Sheffield Teaching Hospitals NHS Trust
Weston Park Hospital Cancer Charity
University of Sheffield James Morrison Fund

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

12155

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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