A study looking at side effects of chemotherapy in cancers of the digestive system (FOCCUS)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Anal cancer
Bile duct cancer
Biliary tree cancers
Bowel (colorectal) cancer
Gallbladder cancer
Liver cancer
Oesophageal cancer
Pancreatic cancer
Small bowel cancer
Stomach cancer





This study is looking at the side effects of chemotherapy that affects the tummy (stomach) and bowels.

More about this trial

Chemotherapy is one of the main treatments for cancer. Unfortunately it does cause side effects. Some side effects, such as being sick (vomiting), have been well researched. There are now treatments available so that sickness can be controlled.

This study is looking at how chemotherapy affects your digestive system, which hasn’t been so well researched.

The aims of this study are to find out

  • How often chemotherapy affects the tummy (stomach) and bowels
  • Why these side effects happen
  • How best to treat side effects of chemotherapy that affect the tummy (stomach) and bowels

Who can enter

You may be able to join this study if have one of the following cancers

You must also be having chemotherapy at the Royal Marsden NHS Foundation Trust and be at least 18 years old.

You cannot join this study if you are a private patient.

Trial design

The researchers need 500 people to take part in this study.

The trial team will ask you to fill out a few questionnaires when you start treatment and every month for a year afterwards. These questionnaires will ask about side effects and how you’ve been feeling. This is called a quality of life study.

They will also ask for a sample of blood, urine and a bowel movement (stool) when you start treatment, at 3 months, 6 months and 1 year. They will use these samples to find out how chemotherapy is affecting you. They will also use the samples to try and predict which people may develop problems from chemotherapy.

Hospital visits

You see a member of the research team to have some tests before taking part in this study. These tests include

  • A physical examination
  • Blood tests
  • Urine test

You then see them every month for a year for a physical examination to see how you are.

The researchers will try and make these appointments at the same time as your other hospital appointments. So you will make as few extra hospital visits as possible.

Side effects

There are no side effects from taking part in this study.

We have information on the side effects of chemotherapy.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

J Andreyev

Supported by

The Royal Marsden NHS Foundation Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 11810

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

Rate this page:

No votes yet
Thank you!
We've recently made some changes to the site, tell us what you think

Share this page