“I was keen to go on a clinical trial. I wanted to try new cancer treatments and hopefully help future generations.”
A study looking at predicting how well chemotherapy before surgery will work for breast cancer (NEO study)
This study is looking at a way of trying to tell in advance how well breast cancer is likely to respond to chemotherapy before surgery.
More about this trial
Doctors often treat breast cancer with chemotherapy before surgery. This is to shrink the cancer so you can have a smaller operation to remove it. We know from research that most cancers respond well to chemotherapy. But unfortunately some don’t. If doctors could tell earlier whether chemotherapy was working or not, some women would be able to avoid having treatment that would not help them.
The researchers will take samples of your cancer and blood samples before you start treatment and during treatment. They will look for
The aim of this study is to find a way of predicting very early in chemotherapy whose cancer is responding.
You will not have any direct benefit from taking part in this study. But the results will be used to help improve treatment for people with breast cancer in the future.
Who can enter
You can join this study if all of the following apply. You
- Are a woman with breast cancer
- Are to have chemotherapy before having surgery to remove your cancer
- Are between 18 and 75 years old
You cannot join this study if any of these apply. You
- Are not able to have chemotherapy
- Have another cancer
- Are pregnant or breastfeeding
The researchers need 100 women who go to the Western General Hospital, Edinburgh to join the study.
You have a sample of your cancer and blood samples taken
- Before starting chemotherapy
- Half way through your chemotherapy
You also give a blood sample at the end of your chemotherapy and then once a year for 5 years.
The surgeon will take another cancer tissue sample when you have your operation.
The study team might ask for another sample of cancer tissue if your breast cancer comes back.
There are no extra hospital visits if you take part in this study.
You may have some bruising and discomfort from where they take the blood and cancer tissue samples.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Olga Oikonomidou
NIHR Clinical Research Network: Cancer