A study looking at MRI scans to assess response to treatment for ovarian, peritoneal or fallopian tube cancer (DISCOVAR)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Ovarian cancer

Status:

Closed

Phase:

Other

This study is looking at a type of MRI scan called ‘diffusion weighted’ MRI scan. This is to measure how well ovarian, peritoneal cancer or fallopian tube cancer respond to treatment. This study is supported by Cancer Research UK.

More about this trial

Doctors often use CT scans and MRI scans to find out how well treatment has worked. These scans are already useful. But doctors are always trying to find ways to improve them.

The researchers think a new type of MRI scan called a diffusion weighted MRI scan may be better. They want to find out if this is so.

Who can enter

To enter this study, you must

There are 2 groups in this study. To be in group 1, you must also be

  • Having chemotherapy with either carboplatin or cisplatin or having a combination of 2 chemotherapy drugs with one being a platinum drug Open a glossary item before having surgery

To be in group 2, you must

  • Have had a CT scan that shows your cancer has come back after treatment
  • Be having chemotherapy with either carboplatin or cisplatin or having a combination of 2 chemotherapy drugs with one being a platinum drug

You cannot enter this trial if you

  • Have serous type ovarian cancer that is low grade
  • Are not able to have an MRI scan, for example because you have a pacemaker or other metal in your body, or are not able to be in confined spaces
  • Are not able to lie flat
  • Have had radiotherapy to your tummy (abdomen) or area between your hips (pelvis) in the past 6 months
  • Have a blocked bowel (bowel obstruction)
  • Have fluid collected in your tummy (ascites) that prevents you having a MRI scan
  • Have had an experimental drug or used an experimental device as part of another clinical trial in the past month
  • Have any other medical condition that could affect you taking part in this study

Trial design

This is an observational study. There are 2 groups in this study. In group 1 the study will recruit 40 women. In group 2 the study will recruit 80 women.

In group 1 you have 2 MRI scans before starting your course of chemotherapy. You have another MRI before your surgery.

In group 2 you have a MRI scan before starting your course of chemotherapy. You have 2 more MRI scans during your course of chemotherapy.

Before each MRI scan you have an injection of a drug called buscopan. This helps relax your bowels to give a clearer picture of your tummy (abdomen).

Hospital visits

You have 3 extra visits to the hospital for the MRI scans. Each scan takes about 40 to 50 minutes.

Side effects

You may have a dry mouth and blurred vision for about 30 minutes after having the buscopan.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Nandita Desouza

Supported by

Cancer Research UK
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

9155

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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