“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study looking at MRI scans to assess response to treatment for ovarian, peritoneal or fallopian tube cancer (DISCOVAR)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
More about this trial
The researchers think a new type of MRI scan called a diffusion weighted MRI scan may be better. They want to find out if this is so.
Who can enter
To enter this study, you must
- Have ovarian cancer (stage 3 or 4), peritoneal cancer or fallopian tube cancer that has spread to another part of the body
- Have a CT scan that shows at least 1 area of cancer that measures at least 2cm across
- Be at least 18 years old
There are 2 groups in this study. To be in group 1, you must also be
- Having chemotherapy with either carboplatin or cisplatin or having a combination of 2 chemotherapy drugs with one being a
platinum drugbefore having surgery
To be in group 2, you must
- Have had a CT scan that shows your cancer has come back after treatment
- Be having chemotherapy with either carboplatin or cisplatin or having a combination of 2 chemotherapy drugs with one being a platinum drug
You cannot enter this trial if you
- Have serous type ovarian cancer that is low grade
- Are not able to have an MRI scan, for example because you have a pacemaker or other metal in your body, or are not able to be in confined spaces
- Are not able to lie flat
- Have had radiotherapy to your tummy (abdomen) or area between your hips (pelvis) in the past 6 months
- Have a blocked bowel (bowel obstruction)
- Have fluid collected in your tummy (ascites) that prevents you having a MRI scan
- Have had an experimental drug or used an experimental device as part of another clinical trial in the past month
- Have any other medical condition that could affect you taking part in this study
This is an observational study. There are 2 groups in this study. In group 1 the study will recruit 40 women. In group 2 the study will recruit 80 women.
In group 1 you have 2 MRI scans before starting your course of chemotherapy. You have another MRI before your surgery.
In group 2 you have a MRI scan before starting your course of chemotherapy. You have 2 more MRI scans during your course of chemotherapy.
Before each MRI scan you have an injection of a drug called buscopan. This helps relax your bowels to give a clearer picture of your tummy (abdomen).
You have 3 extra visits to the hospital for the MRI scans. Each scan takes about 40 to 50 minutes.
You may have a dry mouth and blurred vision for about 30 minutes after having the buscopan.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Nandita Desouza
Cancer Research UK
NIHR Clinical Research Network: Cancer