A study looking at using MRI-PET scanning for cancer of the penis (Hybrid MRI-PET)

Cancer type:

Penile cancer

Status:

Open

Phase:

Other

This study is looking at using a combined MRI and PET scan for men with cancer of the penis.

When you are diagnosed with penile cancer your doctor will feel the lymph nodes Open a glossary item in your groin. This is to see if they can feel anything abnormal which might mean that the cancer has spread to the groins. But only in some men can doctors feel abnormal or enlarged lymph nodes. For the majority of men the lymph nodes will feel normal, even if the cancer has already spread there.

Also not all the abnormalities that doctors can feel in the lymph nodes are caused by the cancer. To make sure that the cancer has caused the abnormality, the doctor needs to take a tissue sample (biopsy Open a glossary item) of the lymph node or remove them with surgery.

The researchers think that a new type of scan that combines an MRI scan and a PET scan may be better at finding out if the cancer has already spread to the lymph nodes in the groin. This scan is called a hybrid MRI-PET scan.

The main aim of this study is to find out how good the MRI-PET scan is at detecting cancer spread to the lymph nodes in the groin of men with penile cancer.

Who can enter

You may be able to join this study if all of the following apply. You

  • Have squamous cell cancer of the penis
  • Are willing to use reliable contraception during the study if there is any chance your partner could become pregnant
  • Are at least 18 years old

You cannot join this study if any of these apply. You

  • Can’t have an MRI scan for some reason (if you have a pacemaker or other metal in your body for example)
  • Can’t have a PET scan
  • Are sensitive to the contrast dye Open a glossary item used for the MRI-PET scan
  • Have diabetes Open a glossary item that isn’t controlled with medication
  • Have any other medical or mental health condition that could affect you taking part in this study

Trial design

The researchers need 107 men to join. Everyone will have a MRI-PET scan.

Before having your MRI-PET scan, your doctor will examine your groin for enlarged lymph nodes.

If your doctor can feel enlarged lymph nodes in your groin, they will take a small sample of tissue from them using a needle (fine needle aspirate Open a glossary item). Or you may have surgery to remove the lymph nodes.

If your doctor can’t feel enlarged lymph nodes in your groin, you will have a Dynamic Sentinel Lymph Node Biopsy. The sentinel lymph node Open a glossary item is the first lymph node where the cancer is likely to spread. You have a radioactive dye injected near the cancer. The doctor uses a probe to find out where the sentinel lymph node is. When the doctor finds the sentinel lymph node, a small cut is made in your groin to remove it.

When you have the MRI-PET scan you cannot eat or drink, apart from plain water, for 6 hours before. You have a small plastic tube (cannula) put in a vein in your arm. The team will inject into your vein a small amount of radioactive material Open a glossary item and a dye (contrast medium Open a glossary item). You have the scan 1 to 1½ hours after having the injections.

With your permission, the study team will take some blood samples and tissue samples of your penile cancer, and lymph nodes only if your doctor can feel anything in them. They may use them in future research to find out more about penile cancer. You don’t have to agree to this. You can still take part in the study.

Hospital visits

You have one extra visit to the hospital for the MRI-PET scan. The scan will take 30 to 60 minutes. But you should expect to be at the hospital for 3 to 4 hours.

Side effects

The MRI-PET scan is a safe test. The amount of radioactive material is very small and shouldn’t cause any side effects.

Very, very rarely, you may have an allergic reaction to the contrast medium injection. This most often starts with sweating, rash and difficulty breathing. The doctors and radiographers will know what to do if you have this type of reaction.

Location

London

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Manit Arya

Supported by

Barts and the London Charity
Experimental Cancer Medicine Centre (ECMC)
Orchid Cancer Charity
Queen Mary University of London

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

11637

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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