A study looking at how to test the genes in lung cancer cells (Stratified Medicine Programme Two - SMP2)

Cancer type:

Lung cancer
Non small cell lung cancer





This study is looking at how to test for changes in the genes of lung cancer cells. It is part of the Cancer Research UK Stratified Medicine Programme.

Currently doctors decide on how to treat a cancer by looking at

  • What type of cancer it is
  • Where it is in your body
  • The size of cancer
  • What the cancer cells look like

We know that this works for many people but not for all. This could be because there are slight differences in the cancer cells from person to person even if they have the same type of cancer. So researchers have been looking in detail at the differences between cancer cells. They've found that some cancer cells have particular proteins in the cell and others don’t. Or sometimes cancer cells have far more of a particular protein than healthy cells. These differences between cells are caused by changes to the genes in the cancer cells.

Researchers want to look at a way to test for these genetic changes. They hope that in the future doctors may be better able to match treatment to the changes in the genes of cancer cells. This is called stratified medicine.

To do this, the researchers need to collect samples of cancer tissue from a large number of people and test them for genetic changes. And to gather information about what treatment they have and what happens to them.

The researchers also want to find out what the costs are to do this and how best it can be used as a part of routine care in the future.

Who can enter

You may be able to enter this trial if you have non small cell lung cancer.

Trial design

This part of the study will recruit up to 4,000 people from around the UK.

The research team will ask for a small piece of tissue taken when you have surgery. If you are not having surgery they can take a sample of tissue removed when you had a biopsy Open a glossary item. They will also ask you for a blood sample.

They will compare the genes of the cancer cells to the genes of your blood cells. This is to find out what changes there are in the cells of the cancer tissue.

They will also ask your permission to look at your medical notes and other health related records to find out about

  • Your cancer
  • Other illness you may have
  • Your treatment now and in the future

Hospital visits

There are no extra hospital visits if you take part in this study.

Side effects

You may have some slight bruising or bleeding from where the researchers take the blood sample.


Newcastle upon Tyne

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Peter Johnson

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

Rate this page:

Currently rated: 5 out of 5 based on 1 vote
Thank you!
We've recently made some changes to the site, tell us what you think

Share this page