"He went through six operations and was placed on a clinical trial so he could try new treatments.”
A study looking at giving radiotherapy after surgery to treat a type of brain tumour called meningioma
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at how effective radiotherapy after surgery can be at preventing a type of brain tumour called meningioma coming back. A meningioma is a tumour that develops from the covering of the brain. They are usually benign (not cancerous). Although benign meningiomas are slow growing, other meningiomas can grow more quickly. Doctors call these atypical (grade 2) or malignant (grade 3) meningiomas.
Doctors usually use surgery to treat meningioma. But those that grow more quickly (are more aggressive) can come back after this, so another treatment is needed to improve the treatment result. Doctors agree that having radiotherapy after surgery can help to stop meningioma coming back. But so far there have not been any studies to find the ideal amount of radiation needed to stop the meningioma growing.
This study will give radiotherapy to people who have had part, or all of their meningioma removed with surgery. The aims of this study are to see
- How long high dose radiotherapy stops the meningioma coming back for
- How well people cope with the treatment
- How well people having the treatment can carry out simple instructions and tasks afterwards
Who can enter
You may be able to enter this study if
- You have a meningioma
- Doctors have said that your meningioma is ‘atypical’ and is at a small risk of coming back after treatment (it is grade 2), or it is the type that grows quickly (grade 3), and doctors call it anaplastic or malignant meningioma
- You have had all or part of your meningioma removed with surgery
- You are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
- You are between 18 and 70 years old
You cannot enter this study if you have
- A growth on the nerve that connects your eye to your brain (your optic nerve)
- A condition that causes growths on the nerve that connects the inner ear with the brain (
- Had radiotherapy to your brain or the covering of your brain (the meninges)
- Had any other cancer
- Any other condition or situation that your doctor thinks would make it difficult for you to take part in the study, or may affect the results of the study
This study will recruit at least 70 people. The type and dose of radiotherapy you have depends on your type of tumour, the surgery you had and the size and position of what is left. If you have had surgery to
- Remove your meningioma completely, you will have 30 radiotherapy sessions
- Reduce the size of your meningioma, you will have 35 sessions of radiotherapy
Your study doctor may prescribe a course of steroids to help protect your brain during the radiotherapy. You will also have a special clear plastic mask made to wear during your radiotherapy. This helps to make sure that the beam is aimed accurately each time.
You will have regular check ups after your radiotherapy to see how you are getting on. Throughout the study your doctor will ask you questions to test your memory and see how well you can draw simple things.
The number of radiotherapy sessions you have depends on your situation. In this study, you may have 30 or 35. So you have a session every week day, for either 6 or 7 weeks.
You will see the team 3 and 6 months after you join the study, for a check up. And then, once a year for the rest of your life or until your cancer gets worse. You will have an MRI scan at each follow up visit, except the first one.
The side effects you have depend on the type of radiotherapy. Possible side effects include
- Red and sore skin where you had your radiotherapy
- Hair loss
- Severe tiredness
- Problems with concentration
- Headache – this is rare
Sometimes radiation can cause a problem called radionecrosis, which is where normal brain cells are damaged by the radiation. This can cause swelling of the brain and fits (seizures). Doctors can usually treat this condition with steroids, but some people may need surgery for this.
The radiotherapy you will have in this study is a type that your hospital uses as routine.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Sarah Jefferies
European Organisation for Research and Treatment of Cancer (EORTC)
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer