A study looking at the genetics of skin cancer

Cancer type:

Non melanoma skin cancer
Skin cancer





This study is trying to find out more about the genetic changes that cause melanoma and non melanoma skin cancers of the head and neck.

The main treatment for skin cancer is surgery. After surgery your doctor may suggest other treatments such as chemotherapy or radiotherapy. Doctors are always looking for ways to improve treatments. To do this they need to understand more about how cancers start and what causes them to grow.

The researchers will collect samples of tissue and blood from people diagnosed with skin cancer of the head and neck. They will use these samples to

  • Identify changes in genes that may have caused the cancer
  • Identify how the body’s immune system responds to the cancer

Who can enter

You may be able to enter this study if you have a skin cancer on your head or neck and are having surgery to remove it at the Southampton University Hospitals Trust or Poole Hospital Foundation Trust.

Trial design

This study will recruit 1,000 people. You fill in a questionnaire before your surgery. This will take about 30 minutes. All the information is confidential Open a glossary item.

The researchers will ask for a sample of tissue taken when you have surgery to remove your cancer. If there is more tissue than needed, they will ask your permission to store it so they can use it for future research.

They will also take a blood sample before surgery and another 3 months after your surgery.

Hospital visits

The researchers don’t anticipate any extra visits. They will try to take the blood samples at your routine hospital visits.

Side effects

The researchers don’t anticipate any side effects if you agree to take part in this study.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Emma King

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Poole Hospital NHS Foundation Trust
University Hospital Southampton NHS Foundation Trust
University of Southampton

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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