“Deborah agreed to take part in a trial as she was keen to help other cancer patients in the future. "If taking part in a trial means others might be helped then I’m very happy with that."
A study looking for biomarkers that show breast cancer may spread (DETECT)
This study is looking for biomarkers of breast cancer that indicate it may spread to the bones. When breast cancer has spread it is called secondary breast cancer.
A biomarker is a substance in the body that doctors can measure, which helps them to tell how a disease is developing or a treatment is working.
More about this trial
Many people with breast cancer are successfully treated every year. But for some, their cancer may spread to the bones. Doctors cannot tell in advance who may get secondary breast cancer in the bones. If they could, they may be able to give treatment early to stop it or slow it down.
In this study the researchers are looking for biomarkers of secondary breast cancer. They will do this by collecting samples of blood, urine, tears and saliva from people with breast cancer and people who have a non cancerous (
The aim of this study is to find biomarkers of breast cancer that show it may spread to the bones.
Who can enter
You can enter this trial if you
- Have breast cancer or may have breast cancer OR
- Have a breast lump which is not cancer
You cannot enter this trial if you
- Are known to be terminally ill and are receiving specialist end of life care
- Are known to be HIV, hepatitis B or hepatitis C positive
This study will recruit about 700 people. The researchers will ask your permission to take some samples. These can include
- Blood samples
- Urine samples
- Tear or saliva samples
For some people, the researchers will take the samples only once. For others, they will take the blood and urine samples on several occasions over 5 years.
The researchers will also ask your permission for a small sample of tissue from when you had breast surgery or a biopsy, if you had these done.
There are no extra hospital visits if you take part in this study. The researchers will take the study samples when you come to the hospital to see the doctor.
As there are no treatments, there are no side effects to taking part in this study. But you may have some discomfort or bruising from where they take the blood sample.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Janet Brown
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Leeds
University of Sheffield