A study looking for changes in genes that cause head and neck cancer (PREGO)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Head and neck cancers
Laryngeal cancer
Mouth (oral) cancer
Nasal and paranasal sinus cancer
Nasopharyngeal cancer
Oesophageal cancer
Pharyngeal cancer

Status:

Closed

Phase:

Other

This study is looking at changes in genes that may cause cancer to develop. This study is open to people with head and neck cancers apart from eye cancer.

Most head and neck cancers can take many years to develop. The stages they most often go through are

  • Normal tissue
  • Abnormal tissue (pre cancerous)
  • Early cancer (carcinoma in situ)
  • Cancer that is growing into the surrounding tissues (invasive cancer)
  • Cancer that may spread

The researchers want to collect samples of cells from all these stages to look at the genes inside them.

The aim of this study is to find out what changes in genes may cause head and neck cancer to develop.

Who can enter

You can enter this trial if you are under the care of the Leeds Teaching Hospitals NHS Trust and you

 

Trial design

This study will recruit between 50 and 150 people a year from the Leeds Teaching Hospitals NHS Trust.

When you have your surgery, or laser treatment, to remove your cancer the researchers will ask your permission for a small piece of the tissue removed. If you have already had treatment, the researchers will ask your permission for a small piece of the tissue from when you had your surgery or biopsy. They will also ask your permission to take a photograph of the sample of tissue. This is for their records only.

They will also ask your permission

  • For a mouthwash
  • For a blood sample
  • To take a brushing of your cancer

To do the mouthwash you hold about a teaspoon of salt water in your mouth and rinse it round for about 30 seconds. You then spit it out into a container.

If you are having a biopsy of your cancer, the researchers will lightly brush the area before with a specially designed brush. This is to collect a sample of the cancer cells.

You can choose if you want to do the mouthwash, have the blood sample or brushing taken.

Hospital visits

Taking part in this study requires no extra hospital visit.

Side effects

You may have some slight bruising or bleeding from where the researchers take the blood sample.

You may feel some slight discomfort from the brushing but this will not last long.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Pamela Rabbitts

Supported by

University of Leeds
Yorkshire Cancer Research

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 7394

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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