“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study looking for changes in genes that cause head and neck cancer (PREGO)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at changes in genes that may cause cancer to develop. This study is open to people with head and neck cancers apart from eye cancer.
Most head and neck cancers can take many years to develop. The stages they most often go through are
- Normal tissue
- Abnormal tissue (pre cancerous)
- Early cancer (
carcinoma in situ)
- Cancer that is growing into the surrounding tissues (
- Cancer that may spread
The researchers want to collect samples of cells from all these stages to look at the
The aim of this study is to find out what changes in genes may cause head and neck cancer to develop.
Who can enter
You can enter this trial if you are under the care of the Leeds Teaching Hospitals NHS Trust and you
- Have squamous cell cancer of the mouth, back of the mouth, nasal cavity and sinuses, voice box or food pipe
- Are having, or have had a small sample of tissue (
biopsy) taken from your cancer
- Are having surgery or
laser treatment, to remove your cancer
- Have had surgery or laser treatment to remove your cancer
This study will recruit between 50 and 150 people a year from the Leeds Teaching Hospitals NHS Trust.
When you have your surgery, or laser treatment, to remove your cancer the researchers will ask your permission for a small piece of the tissue removed. If you have already had treatment, the researchers will ask your permission for a small piece of the tissue from when you had your surgery or biopsy. They will also ask your permission to take a photograph of the sample of tissue. This is for their records only.
They will also ask your permission
- For a mouthwash
- For a blood sample
- To take a brushing of your cancer
To do the mouthwash you hold about a teaspoon of salt water in your mouth and rinse it round for about 30 seconds. You then spit it out into a container.
If you are having a biopsy of your cancer, the researchers will lightly brush the area before with a specially designed brush. This is to collect a sample of the cancer cells.
You can choose if you want to do the mouthwash, have the blood sample or brushing taken.
Taking part in this study requires no extra hospital visit.
You may have some slight bruising or bleeding from where the researchers take the blood sample.
You may feel some slight discomfort from the brushing but this will not last long.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Prof Pamela Rabbitts
University of Leeds
Yorkshire Cancer Research