“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A study looking at cell changes in ovarian cancer (AKTRES)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at changes in ovarian cancer cells when women have a drug called GSK2110183. This study is for women who are taking part in a trial of GSK2110183 with chemotherapy for ovarian cancer.
In this study the researchers want to identify and measure the changes that GSK2110183 causes in cancer cells. To do this, they will take blood samples and tissue samples from women before they start treatment with GSK2110183 and afterwards.
They hope that their research will help predict who may benefit from having treatment. And that future treatment could be better tailored for individual women.
Please note – You won’t get any direct benefit from taking part in this study, nor will it affect any treatment you have. But it may help patients in the future.
Who can enter
You may be able to enter this trial if you are taking part in a trial of GSK2110183 with chemotherapy for ovarian cancer and
- Your ovarian cancer, fallopian tube cancer or primary peritoneal cancer is longer than 2 cm
- Samples of tissue (
biopsies) can be taken from your cancer
- You have had a scan that shows your cancer has continued to grow within 6 months of treatment with
- You are at least 18 years old
You cannot enter this trial if you are taking warfarin or low molecular weight heparin to stop your blood clotting.
This study will recruit 30 people who are also taking part in a trial of GSK2110183 with chemotherapy for ovarian cancer.
When you have blood tests in the trial, extra blood samples will be taken at the same time for this study.
You have a tissue sample (
The researchers will also ask for a sample of your cancer that was removed when you had surgery or a previous biopsy.
If you need to have fluid drained from around your tummy (abdomen), the researchers will take a sample of the fluid.
The researchers will use these samples to find out how GSK2110183 works. They will also use them to develop tests to try and predict who may benefit from this treatment.
You go to the hospital to have the tissue samples taken.
You may have some bruising or bleeding after giving blood samples and tissue samples.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Sarah Blagden
Experimental Cancer Medicine Centre (ECMC)
Imperial College London
NIHR Clinical Research Network: Cancer
Ovarian Cancer Action