A study looking at biomarkers in bladder cancer (Gemtrans)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Bladder cancer
Transitional cell cancer





This study is looking at chemicals and proteins called biomarkers in the blood and urine of people with bladder cancer.

Biomarkers are substances that doctors can measure in the body to help them tell how a disease is developing or how a treatment is working. In this study doctors want to look at biomarkers in people who are having gemcitabine and radiotherapy to treat bladder cancer. They call this combination of treatments GemX.

The aims of this study are

  • To find out more about biomarkers in people having GemX
  • To learn more about bladder cancer and its treatment

Who can enter

You may be able to enter this study if you are under the care of the Christie Hospital, Manchester and

  • You have transitional cell bladder cancer
  • Your doctor wants to treat you with gemcitabine and radiotherapy (GemX)
  • You have satisfactory blood test results
  • You are at least 18 years old

You cannot enter this study if you

Trial design

This study will recruit 50 people.

Everyone taking part will give weekly blood and urine samples while they have GemX treatment. 

The study team will ask you to fill out a questionnaire at each visit during your treatment, again at 6 weeks and then at each of your yearly follow up visits, for 3 years. The questionnaire will ask about side effects and how you have been feeling. This is called a quality of life study.

If you agree to take part in this study, the researchers will also ask for a sample of tissue taken when you had surgery to diagnose your cancer. If you don’t want to give tissue samples for this study, you don’t have to. You can still take part in the study.

Hospital visits

There are no extra hospital visits if you take part in this study. The researchers will take the study samples when you come to the hospital to see the doctor.

Side effects

The only side effect you may have is a small bruise when the blood sample is taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Ananya Choudhury

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
The Christie NHS Foundation Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 9314

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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