“Deborah agreed to take part in a trial as she was keen to help other cancer patients in the future. "If taking part in a trial means others might be helped then I’m very happy with that."
A study looking at physical activity during chemotherapy for breast cancer
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This is a study to see if moderate exercise can help women who are having chemotherapy for breast cancer.
Treatment for breast cancer may include chemotherapy. A common side effect of chemotherapy is tiredness (fatigue), but it can also affect how you feel emotionally. And some people notice changes to their memory, their concentration and how quickly they can work things out. Doctors call this your cognitive functioning.
Researchers want to see if moderate exercise can help. In this study, they are looking at incorporating periods of walking into your daily routine.
The aim of the study is to see if physical activity can improve your cognitive functioning and how you feel during chemotherapy for breast cancer.
Who can enter
You may be able to enter this trial if you
- Have breast cancer that has not spread to another part of your body (stage 1, 2 or 3)
- Are going to have chemotherapy at Leicester Royal Infirmary
- Are female and at least 18 years old
You cannot enter this trial if you
- Have breast cancer that has spread to another part of your body (secondary breast cancer)
- Have had serious mental health problems that could affect you taking part
- Already do more than about 2 ½ hours of moderate exercise each week
This is a randomised study. The women taking part are a put into groups by a computer. Neither you nor your doctors can decide which group you are in.
Women in one group will steadily increase the amount of walking they do as well as having standard care (the intervention group). Women in the other group will have standard care (the
At the beginning of the study, everybody taking part will fill out some questionnaires. These will ask about how tired you feel, how anxious you are and how you feel emotionally. You also do some tests to assess your memory and concentration. You then wear a small device called an accelerometer on your hip for a week. The accelerometer measures your usual level of exercise.
After 2 cycles of chemotherapy, you fill out the questionnaires and do the memory and concentration tests again.
Women in the intervention group then start the physical activity programme for 12 weeks. The researchers will give you a booklet that provides guidance on increasing your level of activity. The aim is to build up to walking 30 minutes 5 times a week. They will also give you a pedometer to wear every day. This measures the number of steps you take. You keep a diary to note down the number of steps you have taken each day. A researcher will phone you regularly to see how you are getting on.
Women in the control group continue with standard care, but at the end of the study, they will be offered the information about increasing their physical activity.
Everybody taking part will complete the questionnaires and do the memory and concentration tests again after 6 cycles of chemotherapy. You will also wear an accelerometer for another week at this time.
A member of the study team will see you when you go to hospital for other appointments. Or if you prefer, they can visit you at home, or you can see them at Loughborough University.
Taking part in this study should not cause you any discomfort. You may find it upsetting filling in the questionnaires. The study team suggest that you contact a member of your medical team or your local support group if you are distressed.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
University Hospitals of Leicester NHS Trust