"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A study looking at blood levels of chemotherapy drugs in people with Ewing's sarcoma (PK 2013 01)
This study is looking at what happens to chemotherapy drugs in the body during treatment for Ewing’s sarcoma. The study is supported by Cancer Research UK.
This study is for both adults and children. We use the term ‘you’ in this summary, but of course if you are a parent, we are referring to your child.
Or you may have vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide, which is called VDC/IE.
We know from research that there are variations in how people get rid of these drugs from their bodies. In this study, researchers are measuring levels of the drugs in the blood after treatment. It is called a
The main aims of the study are to see
- If the blood levels influence the side effects people have and their response to the drugs
- How the blood levels vary in people of different ages
Taking part in this study will not affect the treatment you have. The results may improve the way doctors use these chemotherapy drugs in the future.
Who can enter
You may be able to enter this study if you
- Have Ewing’s sarcoma and are having either VIDE or VDC/IE chemotherapy as part of your treatment
- Have had a tube put into your chest to give drugs directly into one of your major blood vessels (a central line)
You cannot enter the study if
- You are having another type of chemotherapy that is not
- The doctors running the study don’t think it would be right for you to take part
The study will recruit 120 people having chemotherapy for Ewing’s sarcoma.
You have chemotherapy in cycles of treatment. If you take part in this study, the study team will take a number of blood samples during 1 cycle of your chemotherapy treatment.
They will take the first blood sample before you start a cycle of chemotherapy. They then take up to 8 more samples over the next 4 days. They will take the blood from your central line so you won’t need to have any extra needles.
They study team will also take extra samples to study certain genes that may control how fast the drugs are removed from your body and to see if they can predict which patients may be more likely to have side effects. They will take these samples before you start your 1st and 3rd cycles of chemotherapy and when you finish your first type of chemotherapy. The researchers want to see if they can work out at an early stage in treatment who is likely to get infections or a sore mouth because of the chemotherapy.
Taking part in the study doesn’t involve any extra hospital visits.
There are no side effects from taking part in this study.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Quentin Campbell Hewson
Cancer Research UK
The Newcastle upon Tyne Hospitals NHS Foundation Trust
University of Newcastle