A study looking at a diffusion weighted MRI scan to check for bowel cancer spread (SERENADE)

Cancer type:

Bowel (colorectal) cancer
Colon cancer
Rectal cancer

Status:

Open

Phase:

Phase 2

This study is to see if a  scan called a diffusion weighted MRI may help to show up areas of cancer spread more clearly than a CT scan. The study is for people newly diagnosed with bowel cancer who are having a scan to check for cancer spread to the liver.

More about this trial

Doctors use CT scans and MRI scans to check for cancer spread to another part of the body. These scans are useful but doctors are looking at ways to improve them.

Researchers think that a type of MRI scan called diffusion weighted MRI (DW MRI) may be better than a standard CT scan at finding areas of bowel cancer that have spread to the liver. In this study, they want to see how well this scan works for people newly diagnosed with bowel cancer who have a high risk of their cancer spreading or coming back after treatment.

The study will compare the DW MRI scan with a standard CT scan to see which is better at finding possible cancer spread to the liver.

Who can enter

You may be able to join this study if all of the following apply. You

  • Have a type of bowel cancer called adenocarcinoma Open a glossary item
  • Have already had a CT scan which didn’t show any signs of cancer spread to your liver
  • Have a high risk of your bowel cancer spreading or coming back after treatment (your doctor can tell you more about this)
  • Are at least 18 years old

You cannot join this study if any of these apply.

  • Your cancer has spread to another part of your body
  • You have already had chemotherapy for bowel cancer
  • You cannot have an MRI scan for any reason, such as feeling very uncomfortable in small spaces, or having metal or a pacemaker Open a glossary item in your body
  • You have any other cancer apart from non melanoma skin cancer
  • You are pregnant or breastfeeding

Trial design

The study team need 255 people to take part.

Everyone will have a diffusion weighted MRI scan (DW MRI) of their liver. DW MRI looks at the movement of water molecules, which show up differently in cancerous tissue and healthy tissue.

The timing of this scan depends on the type of bowel cancer you have.

If you have cancer of the back passage (rectal cancer) and you are having chemotherapy and radiotherapy, you have this first, followed by a routine MRI scan when you finish treatment. You have the diffusion weighted MRI scan of the liver at the same time as the MRI scan of your rectum.

If you have colon cancer, you have the diffusion weighted MRI scan of the liver within 4 weeks of joining the study.

Hospital visits

If you have colon cancer you will have 1 extra hospital visit for the DW MRI scan. The scan takes about 10 minutes. If you have rectal cancer you will not need to have any extra visits as the liver scan will be done as part of your routine MRI scan.

Side effects

You should not have any side effects from taking part in this study.

Location

Burton on Trent
Gillingham
Liverpool
London
Manchester
Newport
Nuneaton
Portsmouth
Salisbury
Sutton

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Gina Brown

Supported by

NIHR Clinical Research Network: Cancer
Pelican Cancer Foundation
Royal Marsden Biomedical Research Centre
The Royal Marsden NHS Foundation Trust 
The Institute of Cancer Research

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

12430

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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