A study looking at DNA changes in women having treatment for ovarian, peritoneal or fallopian tube cancer

Cancer type:

Ovarian cancer





This study was looking at a cancer gene called PIK3CA, in women having chemotherapy for ovarian cancer, peritoneal cancer or fallopian tube cancer.

All body cells contain deoxyribonucleic acid or DNA. DNA is what our genes are made of. Genes control growth, development and how the body works. There are many differences in DNA from one person to the next. These differences may affect our risk of developing certain diseases, or how we respond to a particular drug.

Researchers wanted to learn more about how gene differences affect the way people respond to treatment for cancer. They were looking for an oncogene Open a glossary item called PIK3CA.

Usually, the only way scientists can study this gene is by looking at samples of cancer tissue under a microscope. In this study, as well as looking at tissue, researchers wanted to see if they could find PIK3CA changes in samples of body fluid, which are easier to collect. This could be from cancer cells or DNA circulating in the bloodstream, or from fluid that had collected in the abdomen (ascites). The aims of this study were to

  • See if it is possible to use circulating DNA to find changes in the PIK3CA oncogene
  • See how often PIK3CA changes appear
  • Try to link these changes with how well the treatment works
  • See if circulating cancer cells and abdominal fluid are sources of cancer DNA

Summary of results

We have contacted the trial team who tell us they don’t expect to be making results available for this trial.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Gordon Jayson

Supported by

Experimental Cancer Medicine Centre (ECMC)
The Christie NHS Foundation Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 5920

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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