A study developing new questionnaires to measure quality of life during treatment for cancer (Quest-Q1)

Cancer type:

Bowel (colorectal) cancer
Breast cancer
Cervical cancer
Ovarian cancer
Vaginal cancer
Vulval cancer
Womb (uterine or endometrial) cancer





This study was done to find the type of questions that are most useful to assess peoples’ quality of life during cancer treatment. This trial was supported by Cancer Research UK.

The researchers wanted to develop different questionnaires for different types of cancer. In this study they looked at people having chemotherapy for bowel cancer, breast cancer or gynaecological cancer.

The aim of this study was to record and analyse consultations between patients and doctors to see the issues raised. The research team then planned to compare them to tools already used to assess quality of life Open a glossary item, and develop 3 new cancer specific tools.

Summary of results

The research team were able to develop 3 cancer specific tools to assess quality of life.

They recorded 564 consultations between 141 patients and their doctors. Of those taking part

  • 17 had bowel cancer
  • 52 had breast cancer
  • 72 had one of the gynaecological cancers such as ovarian or womb cancer

The research team then analysed the consultations to find out what issues were raised. The analysis showed that

  • Those with gynaecological cancers had 40 different issues, and 16 of them weren’t on the existing assessment tool
  • Those with breast cancer had 39 different issues, and 18 of them weren’t on the existing assessment tool
  • Those with bowel cancer had 36 different issues, and 13 of them weren’t on the existing assessment tool

The issues identified were then put into an ‘item bank’, and this was evaluated by 25 health professionals and 30 patients.

From this, the team developed 3 new pilot questionnaires.  448 patients completed the new questionnaires, which included both physical and psychological issues. The results showed that the questionnaires could be useful to assess quality of life.

The research team concluded that they were able to assess factors that affect patients’ quality of life, and develop 3 new tools.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Galina Velikova

Supported by

Cancer Research UK
The Leeds Teaching Hospitals NHS Trust
University of Leeds

Other information

This is Cancer Research UK trial number CRUK/07/058.

We have more information about the work of Professor Galina Velikova.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 7194

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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