A study comparing MRI scan with PET-CT scan for cervical and womb cancer (MAPPING)

Cancer type:

Cervical cancer
Womb (uterine or endometrial) cancer

Status:

Open

Phase:

Phase 2

This study is looking at comparing MRI scan and PET-CT scan for cervical cancer and womb (endometrial) cancer to see which is better in helping doctors see if cancer has spread, and how far. This trial is supported by Cancer Research UK.

Doctors often use MRI scan to find out how far cervical and endometrial cancer has spread. MRI scans are good but doctors are always looking for better ways to find out how far the cancer has spread. A PET-CT scan combines 2 scans, a PET scan using a radioactive tracer and a CT scan. The tracer is a radioactive injection that shows how far the cancer has spread.

The researchers think another type of MRI scan (DW MRI scan) or a PET-CT scan may be better than a standard MRI scan. The researchers will also look at 2 different radioactive tracers used for the PET-CT scan.

The researchers want to compare the standard MRI scan with the DW MRI scan and PET-CT scan to find out which is better at showing how far cervical and endometrial cancer has spread.

Who can enter

You may be able to enter this study if you have either

OR

AND

  • You are having surgery to remove your lymph nodes
  • You and your partner are willing to use reliable contraception if there is any chance you could become pregnant
  • You are at least 18 years old

You cannot enter this study if you

  • Can’t have surgery to remove your lymph nodes
  • Can’t have a MRI scan for example you have a pacemaker or metal in your body or you cannot cope with being in a small space
  • Can’t have a PET-CT scan
  • Are having an experimental drug as part of another clinical trial
  • Are due to have scans as part of another clinical trial at the same time as the scans for this study
  • Have a medical condition that could affect you taking part in this study
  • Are pregnant or breastfeeding

Trial design

This is a phase 2 study. It will recruit up to 150 women. Everyone taking part will have a

  • MRI scan
  • DW MRI scan
  • PET-CT scan

The researchers will ask you if you are willing to have another PET-CT scan using a different radioactive tracer.

After your scans your doctor will talk to you about surgery.

Hospital visits

You have 2 or 3 extra visits to the hospital for the extra scans.

If you are having the 2nd PET-CT scan you may need to visit another hospital.

Side effects

You shouldn’t have any side effects from having the MRI scan.

You will be exposed to a little extra radiation by having the study PET-CT scan. We are all exposed to a very small amount of radiation during the course of a normal day (background radiation). The amount of radiation you would have from the extra CT scan is about the same as several years of background radiation, and is thought to be low risk.

We have more information about MRI scan and PET-CT scan in our cancer tests section.

Location

Birmingham
Cambridge
London
Preston
Sutton

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Andrea Rockall

Supported by

Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
Cancer Research UK
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

9043

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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