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Doxifos (doxorubicin and ifosfamide)

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This page tells you about the chemotherapy drug combination doxorubicin and ifosfomide and its possible side effects. There is information about


Doxorubicin and ifosfamide combination chemo

Doxorubicin and ifosfamide is the name of a combination of chemotherapy drugs used to treat soft tissue sarcoma. 

This combination is sometimes called dox-ifos or Doxifos. It is made up of the drugs

  • Doxorubicin (also known as Adriamycin)
  • Ifosfamide

The links above take you to information about the individual side effects of each of these drugs.

The side effects of a combination of drugs are usually a mixture of those of each drug. The combination may increase or decrease your chance of getting each side effect or it may change the severity. The side effects associated with Doxifos are listed below. You can use the underlined links to find out more about each one. 

For general information, see our cancer drug side effects section or use the search box at the top of the page.


How you have doxifos treatment

You usually have chemotherapy as cycles of treatment. The doxorubicin and ifosfamide chemotherapy can be given in several ways. They are all similar and each cycle lasts for 3 weeks. But the number of days you have treatment during each cycle varies between 1 and 5 days. You may have between 4 to 6 cycles. This takes between 3 and 4 months.

Doxorubicin is a red fluid. Ifosfamide is a clear fluid. You have the drugs into your bloodstream (intravenously). You can have them through a thin, short tube (a cannula) put into a vein in your arm each time you have treatment. Or you may have them through a central line, a portacath, or a PICC line. These are long, plastic tubes that give the drugs directly into a large vein in your chest. The line stays in place as long as you need it.

You may have both drugs by drip (infusion) or doxorubicin may be given by injection into your central line. You usually have ifosfamide with another drug called mesna. Mesna is not a chemotherapy drug. It stops the ifosfamide from irritating your bladder and causing bleeding. You usually have mesna into a vein, but sometimes you have it as tablets you take at home. It is very important that you take the mesna according to the instructions your doctor or nurse gives you or you may have worse side effects from the chemotherapy. 

Schedules for doxorubicin and ifosfamide chemotherapy

There are different ways (schedules) of having doxorubicin and ifosfamide chemotherapy. Your doctor or nurse will discuss with you which one you have and why. Some of the commonly used ones are described below.

Schedule A

On the first day of the treatment cycle you start an ifosfamide and mesna drip which continues for 3 days. Sometimes you may have this for 5 days. You also have a slow injection of doxorubicin through your cannula or central line on the first, second and third day. You need to stay in hospital for this treatment. When the drip is finished you can go home. You then have no treatment for the next 16 to 18 days. Then you start the next cycle.

Schedule B

On the first day of the treatment cycle you have an injection of doxorubicin plus a four hour drip (infusion) of ifosfamide. You take mesna as tablets. This treatment is repeated on day 2 and day 3. Having treatment in this way means that you don’t have to stay in hospital for the whole 3 days. You can go home each day in between your treatments. After the third day of treatment you have no treatment for 18 days. Then you start the next cycle.

Schedule C

On the first day of the treatment cycle you have an injection of doxorubicin into your cannula or central line plus a four hour drip (infusion) of ifosfamide. You have a mesna injection before you start the ifosfamide infusion and another two doses four and eight hours later. You have this treatment again the next day. You will probably need to stay in hospital for the 2 days of treatment. You can then go home and have no treatment for 19 days. Then you start the next cycle.

Schedule D

On the first day of the treatment cycle you have an injection of doxorubicin plus a 24 hour drip (infusion) of ifosfamide. You have a mesna injection before you begin your ifosfamide drip and also a 24 hour mesna infusion running alongside your ifosfamide. You will need to stay in hospital overnight. You then go home and have no treatment for 20 days. Then you start the next cycle.


Common side effects

More than 10 in every 100 people have one or more of the side effects listed below.

  • An increased risk of getting an infection from a drop in white blood cells – it is harder to fight infections and you can become very ill. You may have headaches, aching muscles, a cough, a sore throat, pain passing urine, or you may feel cold and shivery. If you have a severe infection this can be life threatening. Contact your treatment centre straight away if you have any of these effects or if your temperature goes above 38°C. You will have regular blood tests to check your blood cell levels
  • Tiredness and breathlessness due to a drop in red blood cells (anaemia) – you may need a blood transfusion
  • Bruising more easily due to a drop in platelets – you may have nosebleeds, bleeding gums after brushing your teeth, or lots of tiny red spots or bruises on your arms or legs (known as petechia)
  • Tiredness and weakness (fatigue) during and after treatment – most people find their energy levels are back to normal within 6 months to a year
  • Feeling or being sick – this is usually well controlled with anti sickness medicines. If you are still being sick, tell your doctor or nurse
  • Complete hair loss affects nearly everyone who takes these drugs. This is temporary and your hair will grow back after the treatment ends
  • A sore mouth can affect up to 5 out of 10 people
  • Sensitivity to the sun – cover up and stay in the shade while you are having this treatment
  • Watery eyes occur in more than 2 out of 10 people – it may last for several days after the start of each treatment
  • Doxorubicin can make your urine turn pink for one or two days after treatment but this won't harm you
  • Ifosfamide can cause irritation of the bladder and kidneys – it is important to drink as much water as possible to flush it out. You may have fluids into your drip before and after your treatment. You should take your mesna treatment as prescribed
  • Your nails may become ridged – or they may get darker and white lines may appear on them
  • Women may stop having periods but this may be temporary
  • Loss of fertility – you may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men may be able to store sperm before starting treatment
  • More than 1 in 10 people (12%) have confusion, sleepiness or extreme lack of energy (lethargy) and hallucinations – let your doctor or nurse know straight away if you have any of these
  • Diarrhoea occurs in more than 1 in 10 people (12%) – drink plenty of fluids and tell your doctor or nurse if diarrhoea becomes severe or continues for more than 3 days

Occasional side effects

Between 1 and 10 in every 100 people have one or more of these effects.

  • Temporary liver changes – you will have blood tests to see how well your liver is working
  • A skin rash, which may be itchy
  • Reddening of the skin in areas where you have had radiotherapy in the past. The skin may get dry and flaky and feel sore and hot. This goes away on its own but keep affected areas out of the sun
  • Temporary darkening of the skin
  • Inflammation around the drip siteif you notice any signs of redness, swelling or leaking at your drip site, tell your chemotherapy nurse straight away
  • An allergic reaction affects 3 people out of 100 (3%) when they have doxorubicin – let your nurse know if you feel hot or have any skin rashes, itching, dizziness, headaches, shivering, breathlessness, anxiety, flushing of the face, or a sudden need to pass urine
  • Damage to heart muscle, which is usually temporary but for a small number of people may be permanent – your doctor will check your heart before and after your treatment
  • Loss of appetite
  • A high temperature (fever) and chills

Rare side effects

Fewer than 1 in 100 people have these effects.

  • Sore eyes
  • If you have a high dose or many treatments with doxorubicin there is a small risk that you may get a second cancer some years later

Important points to remember

You may only have 1 or 2 side effects or you may have a few. A side effect may get worse through your course of treatment. Or you may have more side effects as the course goes on. This depends on

  • How many times you've had a drug before
  • Your general health
  • How much of the drug you have (the dose)
  • Other drugs you are having

Coping with side effects

Talk to your doctor, pharmacist or nurse about all your side effects so they can help you manage them. They can give you advice or reassure you. Your nurse will give you a contact number to ring if you have any questions or problems. If in doubt, call them.

Other medicines

Tell your doctor about any other medicines you are taking, including vitamins, herbal supplements and over the counter remedies. Some drugs can react together.

Pregnancy and contraception

These drugs may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.


Do not breastfeed during this treatment because the drugs may come through in the breast milk.


Immunisations and chemotherapy

You should not have immunisations with live vaccines while you are having chemotherapy or for at least 6 months afterwards. In the UK, these include rubella, mumps, measles (usually given together as MMR), BCG, yellow fever and Zostavax (shingles vaccine).

You can have other vaccines, but they may not give you as much protection as usual until your immune system has fully recovered from your chemotherapy. It is safe to have the flu vaccine.

It is safe for you to be in contact with other people who've had live vaccines as injections. There can be problems with vaccines you take by mouth (oral vaccines), but not many people in the UK have these now. So there is usually no problem in being with any baby or child who has recently had any vaccination in the UK. You might need to make sure that you aren't in contact with anyone who has had oral polio, cholera or typhoid vaccination recently, particularly if you live abroad.


Related information


More information about doxifos

This page does not list all the very rare side effects of this treatment that are very unlikely to affect you. For further information about these drugs look at the Electronic Medicines Compendium website at

If you have a side effect not mentioned here that you think may be due to this treatment you can report it to the Medicines Health and Regulatory Authority (MHRA) at

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Updated: 6 October 2014