Panmyelosis
Panmyelosis is usually referred to as acute panmyelosis with myelofibrosis (APMF) or acute myelofibrosis.
Myelofibrosis means there is scar tissue inside the 
instead of normal tissue. This causes panmyelosis, which means that the bone marrow can't produce enough red blood cells, white blood cells or platelets.
APMF is a very rare form of acute myeloid leukaemia (AML). It's a disease that is difficult to diagnose and often develops very quickly.
Blood cells and leukaemia
To understand how and why leukaemia affects you as it does, it helps to know how you make blood cells.
Your body makes in the bone marrow. The bone marrow is the soft inner part of your bones. You make blood cells in a controlled way, as your body needs them.
All blood cells start as the same type of cell, called a stem cell. This stem cell then develops into:
- myeloid stem cells become white blood cells called monocytes and neutrophils (granulocyte), red blood cells and platelets
- lymphoid stem cells, which become white blood cells called lymphocytes
The diagram below helps to explain this.
In acute myeloid leukaemia, the bone marrow makes too many monocytes or granulocytes. These cells are not fully developed and are not able to work normally.
In other types of leukaemia, usually only one type of myeloid cell becomes cancerous. But in APMF more than one type of myeloid cell is abnormal. Usually, cells called megakaryocytes are also abnormal in APMF.
Megakaryocytes are the cells that go on to become platelets. So it is sometimes confused with a type of leukaemia called acute megakaryoblastic leukaemia.
Symptoms and diagnosis of APMF
In APMF, the levels of red blood cells, white blood cells, and platelets are low. This is called pancytopenia. This can cause:
- infections
- tiredness
- bleeding
Rarely, you may have a feeling of fullness or discomfort in your tummy (abdomen). This can be caused by a swollen .
Seeing a specialist
Your GP should arrange for you to have a blood test or see a blood specialist (haematologist) if you have symptoms that could be due to acute myeloid leukaemia. You're usually referred very quickly.
Your specialist will try to take a sample (biopsy) of the bone marrow. They look at the cells under a microscope to check for leukaemia cells.
Overview of treatment for APMF
APMF is very rare and there is no . Most specialists are likely to treat it in the same way as other types of acute myeloid leukaemia (AML). Often symptoms become worse very quickly.
You may have chemotherapy and you might have a . Your healthcare team will consider the benefits of treatment and the possible side effects. For example, the treatment can temporarily reduce someone’s ability to fight infection, even more than the leukaemia does. Your team will explain things to you in more detail and monitor you carefully during treatment.
Side effects of APMF treatment
The side effects of APMF treatment will vary from person to person. Not everyone gets these side effects, but you are closely monitored when you have this treatment.
We have detailed information about the side effects of treatment on each cancer drug page.
Coping with APMF
Coping with a diagnosis of a rare cancer can be especially difficult. Being well informed about your cancer and its treatment can help. It can make it easier to make decisions and cope with what happens.
Talking to other people who have the same thing can also help.
Our discussion forum Cancer Chat is a place for anyone affected by cancer. You can share experiences, stories and information with other people.
You can call our nurse freephone helpline on 0808 800 4040. They are available from Monday to Friday, 9am to 5pm. Or you can send them a question online.
The Rare Cancer Alliance offer support and information to people with rare cancers. It has a forum where you might be able to meet others with the same cancer as you.
