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Goserelin (Zoladex)

Read about goserelin, how you have it and other important information about taking this hormone therapy drug for breast cancer. 

What is it?

Goserelin is also known by its brand name Zoladex. It is a type of hormone therapy called a luteinising hormone (LH) blocker. 

This means that it stops the release of luteinising hormone from the pituitary gland. In women, this stops the ovaries from producing oestrogen. In men, it stops the testicles producing testosterone.

Goserelin is a treatment for women who have breast cancer that has oestrogen receptors (ER positive) and who have not yet reached menopause.   

How you have it

You have goserelin as an injection just under the skin of your tummy (abdomen). It is called a depot injection, which means that the drug is slowly absorbed into your body over a period of time. 

You usually have goserelin every 28 days. 

Injection under your skin

Tests during treatment

You might have blood tests before starting treatment and during your treatment. They check your general health and might check your levels of blood cells and other substances in the blood.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This drug may harm a baby developing in the womb. Let your doctor or nurse know before you start treatment if there is any possibility that you may be pregnant. It is important not to become pregnant while you are having treatment and for a few months afterwards. Goserelin is not a contraceptive and, even if your periods have stopped, you could become pregnant while you are having treatment. 

It is important to use reliable contraception, such as the condom or cap (diaphragm), throughout the treatment. Don't take the pill (oral contraceptive). Discuss this with your doctor or specialist nurse. Talk to your doctor or nurse about effective contraception before starting treatment.

Breastfeeding

Don’t breastfeed during this treatment because the drug may come through in your breast milk.

Treatment for other conditions

Always tell other doctors, nurses or dentists that you’re having this drug if you need treatment for anything else, including teeth problems.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

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