Read about cyproterone acetate, how you have it and other important information about taking this hormone therapy.
Cyproterone is a hormone therapy and is also known by its brand name Cyprostat. It is a type of drug called an anti androgen.
It is a treatment for prostate cancer.
You take cyproterone acetate either on its own, or with another type of drug for prostate cancer called a luteinising hormone (LH) blocker.
LH blockers include:
- Goserelin (Zoladex)
- Leuprorelin (Prostap)
- Triptorelin (Decapeptyl SR, Gonapeptyl Depot)
You might have cyproterone acetate with a luteinising hormone blocker to stop what is called a flare reaction. When you first start taking LH blockers you actually make more testosterone for the first few days or weeks, which increases the symptoms of the prostate cancer. This soon settles down, and after a few weeks you stop making testosterone. Cyproterone acetate helps to reduce any cancer symptoms caused by this temporary increase in testosterone.
Cyproterone can also help to reduce hot flushes in men:
- who have had their testicles removed as a treatment for prostate cancer
- who are taking luteinising hormone (LH) blockers
How it works
Prostate cancer cells depend on the hormone testosterone in order to grow. Cyproterone lowers levels of testosterone in the body and also blocks testosterone from reaching the cancer cells. It slows or stops the growth of prostate cancer.
How you have it
You take cyproterone acetate as a tablet 2 or 3 times a day, with water after meals. Try to take it at evenly spaced times during the day.
If you are having it to stop a flare reaction, you take it for a few days before starting the luteinising hormone blocker, and stay on it for about 4 to 6 weeks.
When you stop taking cyproterone you need to reduce the dose gradually. Your doctor will tell you exactly how to do this.
Taking your tablets or capsules
You should take the right dose, not more or less.
Never stop taking a cancer drug without talking to your specialist first.
Tests during treatment
You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
Other medicines, foods and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
Avoid drinking alcohol while having this treatment because alcohol reduces the effect of the drug.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
If you have diabetes
This drug may affect your blood sugar levels if you have diabetes. You need to check your blood sugar more often when you are having this treatment.
It is important not to father a child while you are having treatment with this drug and for a few months afterwards. This drug may harm a baby developing in the womb. Talk to your doctor or nurse about effective contraception before starting treatment.
This drug can cause infertility in some men, but it is usually temporary. Fertility can return some months after treatment ends but the time it takes can vary. The effects of long term treatment on fertility is not known.
Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
More information about this treatment
For further information about this treatment go to the electronic Medicines Compendium (eMC) website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.