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Cisplatin and Teysuno

Find out what cisplatin and teysuno is, how you have it and other important information about taking this drug combination. 

Teysuno (prounounced tay-soon-oh) and cisplatin is a chemotherapy drug combination used to treat advanced stomach cancer. Advanced stomach cancer means that it has spread outside the stomach.

How it works

Teysuno is made up of tegafur, gimeracil and oteracil. Tegafur is changed into a drug called fluorouracil in the body. It is one of a group of chemotherapy drugs known as anti metabolites. 

These drugs stop cells making and repairing DNA. Cancer cells need to make and repair DNA in order to grow and multiply. 

Cisplatin is a chemotherapy drug that works by damaging the DNA in cancer cells and stopping them from multiplying. 

How you have it

You have cisplatin through a drip into a vein (intravenously). 

Teysuno is a capsule that you take twice a day, morning and evening. You swallow them whole with plenty of water. You should take the capsules either an hour before eating or an hour after eating. 

Drugs into your bloodstream

You have the treatment through a drip into your arm. A nurse puts a small tube (a cannula) into one of your veins and connects the drip to it.

You might need a central line. This is a long plastic tube that gives the drugs into a large vein, either in your chest or through a vein in your arm. It stays in while you’re having treatment, which may be for a few months.

Taking your tablets or capsules

You must take tablets and capsules according to the instructions your doctor or pharmacist gives you.

You should take the right dose, not more or less.

Never stop taking a cancer drug without talking to your specialist first.

When you have it

You have this chemotherapy combination as a course of several cycles of treatment. Each cycle of treatment lasts 28 days (4 weeks). Depending on your needs, you may have up to 6 cycles of cisplatin and teysuno. 

You usually have each cycle of treatment in the following way. 

Day 1
  • You have cisplatin as a drip into your bloodstream over about 2 hours
  • You take Teysuno capsules twice a day

You also have other fluids as a drip into your bloodstream before and after you have cisplatin. This helps to keep you hydrated. In total it can take about 6 hours. 

Day 2 to 21
  • You take Teysuno capsules twice a day
Day 22 to 28
  • You have no treatment

You then start a new cycle of treatment. After 6 cycles of cisplatin and Teysuno, you usually continue taking Teysuno for as long as it works. 

Tests during treatment

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Pregnancy and contraception

This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.


Don’t breastfeed during this treatment because the drug may come through in your breast milk.

Treatment for other conditions

Always tell other doctors, nurses or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.


Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.

In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and Zostavax (shingles vaccine).

You can:

  • have other vaccines, but they might not give you as much protection as usual
  • have the flu vaccine
  • be in contact with other people who've had live vaccines as injections

Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, you mustn't change their nappies for 2 weeks after their vaccination.

You also need to avoid anyone who has had oral polio or typhoid vaccination recently.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Last reviewed: 
05 Jul 2017
  • Influenza vaccines in immunosuppressed adults with cancer
    Noa Eliakim-Raz and others
    Cochrane Database of systematic reviews, 29 October 2013

  • Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study

    N. Boku and other. The Lancet Oncology, November 2009

  • Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial

    J. A. Ajani and others. Journal of Clinical Oncology. March 2010.

  • Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1 M otastat potassium) in advanced gastric cancer patients

    Y. Sakata and others. European Journal of Cancer, October 1998 

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